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Amlodopine - night time peeing.

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Amlodopine - night time peeing.

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Old 11th Jun 2018, 13:35
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Amlodopine - night time peeing.

Both MIL and myself are on Amlodopine for high BP and having compared notes, seem to need to pee every 2-3 hours at night. Could this also be related to the fact we also tend to suffer from puffy ankles (water retention) Iím seeing my doctor about an unrelated issue this week anyway so wonder if itís worth mentioning.
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Old 11th Jun 2018, 16:55
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https://www.rxlist.com/norvasc-side-...rug-center.htm
Common side effects of Norvasc include:
  • headache,
  • swelling (edema) of the ankles or feet,
  • dizziness,
  • lightheadedness,
  • drowsiness,
  • tired feeling,
  • nausea,
  • abdominal or stomach pain, or
  • flushing (warmth, redness, or tingly feeling).
http://labeling.pfizer.com/ShowLabel...62&section=ppi
What are the possible side effects of NORVASC?

NORVASC may cause the following side effects. Most side effects are mild or moderate:
  • swelling of your legs or ankles
  • tiredness, extreme sleepiness
  • stomach pain, nausea
  • dizziness
  • flushing (hot or warm feeling in your face)
  • arrhythmia (irregular heartbeat)
  • heart palpitations (very fast heartbeat)
  • muscle rigidity, tremor and/or abnormal muscle movement

So your swollen ankles may be caused or exacerbated by amlodopine, but there's no mention of frequent urination, despite it being a common side effect of some blood pressure medications.
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Old 11th Jun 2018, 17:22
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Looks like there can be a connection between Nocturia and Amlodipine - see Case 2:

https://www.nps.org.au/australian-pr...s-and-nocturia
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Old 11th Jun 2018, 18:02
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I've been on 10mg/day Amlodopine since 2003 and never suffered any change to night time urination. That said, I do have very slightly swollen ankles (almost negligible) but none of the other side effects listed above. I flew the last twelve years of my professional career with it and frankly have BP readings that are so low that I would like to come off it. Sadly both my AME and GP are aligned on the 'If it ain't broke don't fix it' approach' so I don't think they'll let me.

Any change in Nocturia is more likely to be related to ageing and prostate size, along with altered personal tolerances to the bladder when asleep.
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Old 11th Jun 2018, 20:09
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Are you on any other meds ?

It's worth having a chat with your GP if nocturia is a new (ish) symptom, irrespective of the amlodipine.
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Old 11th Jun 2018, 20:37
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Originally Posted by gingernut View Post
Are you on any other meds ?

It's worth having a chat with your GP if nocturia is a new (ish) symptom, irrespective of the amlodipine.
Thanks, also on statins.
Had the issue for two years plus. Blood tests for diabetes etc all ok and PSA negligible - as my dad has been treated for prostate cancer, the doctor has been particularly hot on that one.
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Old 14th Jun 2018, 18:05
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Thanks for reply CC - much appreciated,

Doc said pretty much the same. I’m on the 10mg dose and, as with any medication, you have to balance the good with the bad. The amlodipine is doing a good job keeping my bp steady so she said she is reluctant to mess about with it, unless the nocturnal visits are impossible to live with. Like yourself, she suggested taking the tablets in the evening rather than morning and look at bladder exercises too!
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Old 15th Jun 2018, 09:03
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I think you have to accept that your "plumbing" gets weaker as you get older, another legacy besides grey hair and insomnia!
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Old 15th Jun 2018, 19:59
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Thanks, also on statins.
Had the issue for two years plus. Blood tests for diabetes etc all ok and PSA negligible - as my dad has been treated for prostate cancer, the doctor has been particularly hot on that one.
Sounds like The Doctor has covered all the bases. Obviously, if anything changes, it's worth a re-visit.

I've prescribed amlodipine, simvastatin and atorvastain, widely for patients with hypertension, and urinary frequency isn't a common symptom. There could be some mileage in adjusting the dose (they have a long half life), but obviously back this up with your prescriber,

Maybe worth considering other causes as well, my first thing would be to rule out the obvious (chlamydia and the such like).
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