You asked a question which as you well knew had no answer since there are no regulatory standards yet.
In terms of technological rather than regulatory challenges, there are autonomous aircraft flying today that are achieving vastly more tricky aspects of flight than airliner ops.
If you can successfully and consistently land on an aircraft carrier, then a runway is zero challenge.
If you can air-to-air refuel, then most other challenges pale into relative insignificance.
As I see it the tricky part will be the handover to an automated ATC, but it is not beyond the wit of man.
If you rephrase the question to exclude the unachievable bit re non-existent regulations, then yes I absolutely claim that the tech required already exists. There are no new technologies required, merely the will to place them all in a suitable airframe.