The US ANG now operates units at 16 of the 18 Air Sovereignty Alert Sites (QRA in NATO parlance) and has resolved 3400+ air threats since 2001. [source ANG website].
They currently operate the F-22, F-15C/D and F-16. There is concern about how to recapitalize the F-16 Block 30 fleet around 2020.
A few live scramble take-offs:
https://www.youtube.com/watch?v=X2VrsRiSjfY
https://www.youtube.com/watch?v=Sfn2_QnlUeU