High terrain, bad weather, R/w 17 is out of question at night, so be careful of tendencies to shoot approach with any tailwind, the R/w slopes down so you can’t see the end of r/w, pilots tend to use heavy braking due to that (many burst tires), so develop the procedure to call remaining distance which is available, by the PNF, Suggest to be Captains Ldg only, High crew coordination is vital, Ground proximity warnings are very common, so should really set limits to deviations. Language barrier should be taken into consideration, speak clearly and use aviation terminology only. Some people get really tired and depressed or mood changes on gnd because of the height so take it easy with the exercise, at the hotels normally O2 bottles are available on request. Eng out procedures should be briefed before each T/o as it is not normal, and has a special pattern. (Need to circle in the valley) If you lose an eng enroute do not land at Quito, better find a better place. Pressurization would have a difference to what you are normally used, as you need to climb the cabin instead of the normal descent. Know your tire speed limits and call the gnd speed on final. Be careful with wet R/w's .due rubber deposits you'll find slippery.