While the below link has absolutely diddly squat to do with LTN, I think this can firmly put to bed the query that regularly comes up, which is that Luton will need a runway extension in the years to come, if it wants to attract long haul carriers...
Thomson first Dreamliner flights from Bristol on sale this month
Bristol's runway is over a 1000ft shorter than Luton's, if they can operate a Thomson's 787 direct to Florida and Mexico, it should definitely be more than capable of flying similar length routes from the airport.
As many have however said, the demand is questionable, but with LHR and LGW brimming full, the chances are slightly there, at some point in the future.