Request to all regulators to impose a limit to changes in circadian rythms.
Ie a briefing at 10 pm,landing at 6 am followed by a briefing at 4 am followed by a landing 10 am ,followed by four sectors starting at 4 pm ending at midnight.
That would be a good start,see what they say.
Only regulators can change fatigue issue,airliners are just using the rules to the extreme,just as tax evaders do.