What chance Shaheen Air could end up flying to/from LTN - seems a reasonable idea?
Could a fully loaded A330 use the LTN runway to say ISB?
I wouldn't hold out your hopes, but say 3-4 flights a week could possibly work.(?)
The problem is all the competition down the road at LHR with BA and PIA. Also the Middle East airlines operate extensively to this region, with just a single change in DXB, AUD and DOH. Making this a very competive market.
The Pakistan is a large country, and you need to serve a number of cities in the country to pull in a large sector, like Karachi, Islamabad and Lahore.
An A330-200 should be able to operate the route, wich out too much difficulty, Monarch use to use their's between Luton-Orlando on a weekly charter. Around 2001-2003.
Not sure about the A330-300, that is probably more questionable.