IOM is very nostalgic isnt it. From what I have read everywhere else it would not be worth re-opening the route.
I think more Scandinavia and more Italy must be in store. Ryanair operates a huge load of flights to Italy from STN yet Luton has hardly any. Bring back Palermo. Places like Bari, Genoa, Florence, Bologna and Cagliari could be given a shot. Trapani or Ragusa also on the island of Sicily. With the way things are going in the Middle East and the trouble in Turkey I expect tourism in Southern Italy will grow rapidly in the coming years.
Athens, Frankfurt, Seville, Toulouse, Oslo, Stockholm, Helsinki? Talinn.. a connection to Russia? Lviv in UKR? Tunis.. Aiming a bit higher Boston/Toronto when the likes of the A321 LR come into operation. I know I know, These are just suggestions not routes I am expecting.