Oporto could be 2 weekly to 2 destinations.
I actually hope Lisbon does not feature from Manchester.
TAP are increasing to 14 weekly next summer, and Ryanair are at 5 weekly so I believe 19 weekly is sufficient for the time being.
One I would hope is expanded is Tel Aviv now that Monarch have announced LTN-TLV. It's a sector that could be shoe-horned into any vacated Sharm cuts, and Manchester could do with some extra frequency to TLV