Despite the fact that I am on "voluntary" unpaid leave from my job in the Far East, I have never felt more rested or relaxed in my entire aviation career. There is no doubt about it, ULH takes a slow, steady toll on your health and well-being. Add the post 9/11 hysteria, SARS, SLF's and industrial B-S that have been part of the past 9 years where I work, and frankly, retirement (still 13 years away) is looking better and better...
A few words of advice to those who may feel that it's just too much:
Rationalise the relationship that you have with your employer and with flying in general. Decide what they want from you, and what you want from them. Most important, don't take it home.
Fly safe.