I used AVGAS 100LL in my drag-kart which had a 250cc Honda 2-stroke engine Sometimes difficult to start but when running it was superb, especially as I had a 'skimmed' cylinder head with a squish clearance about half standard (gawd knows what the C/R was!). Having said that, I understand from microlighting that any leaded fuel can be detrimental to 2-strokes in the long run, but in drag racing, you don't run the engine very long so it doesn't matter as much as (say) a circuit racer.
Several 4 - stroke operators at the drag racing used 100LL too.