And slow. Maybe on one engine?
Hard to imagine even a freighter flying past that many suitable airports on one engine. Or, with an emergency of any sort.
Loss of pressurization perhaps with fuel burn back to EDDF enough to get down to landing weight? Still, would you press on all the way back to FRA at FL 190 wearing masks?
Or, loss of altimetry redundancy and inability to do RVSM? Would you squawk 7700?
Nav failures and unable MNPS?
The plane is now headed east, suddenly not going on a course back to Frankfurt.