Doubt it - have you seen the size of the DHL facility at East Midlands? There and Leipzig are their main Euro hubs, which already have US flights, so feeding Leipzig (who also have long haul connections to the east) would make more sense. Given that East Midlands is only 90 minutes away from MAN by road I'm actually surprised that they would consider a flight from here, and can only think that they believe they can fill a 757 several times a week. Given that FedEx can't (our flight goes via Birmingham of course) then we may be suffering from spotters overenthusiasm again - time will tell.
Possibly the main angle in our favour is that the EMA facility does seem very busy, so it may be that a MAN flight would take off some of the pressure there.