I'm sure it's been said somewhere that it's a new route, which I suppose has been interpreted as a new destination. If it's a new route for a particular airline from MAN, but not necessarily a new destination, then EK to JFK could fit the bill.
That, I have to say, would be more interesting i.m.o. than PIA to LAX with MAN really being mainly a refuelling stop and presumably for security purposes.
Also, it has not been established whether it is a transit flight via MAN or a MAN originating flight; or even that it's to the US, although that seems likely on the hints given.