Right now the industry is such that jobs are few and far between. And what jobs there are are covered with several inches (CM to you guys) of resumes (CVs to you guys) and it is expected to be that way for the near future. The industry is going through a major shake up right now. Having been through this before, I believe it will be at least a year or two before an upturn is seen.
To be employed by a US operator, you will need a 'green card'. Like any other country you can not work here in the US without the right to work authority. Most if not all employers will NOT sponser you for this paperwork. The few they will sponser are high qualified people hire for a special reason.
Any operator here in the US will require you to have FAA certificates. Other ICAO certificates are not acceptable. And like Europe conversion can be an effort. While the airlines' published pilot requirements are accually very low, the reality is that they tend to hire pilots with much higher experience levels.