MAN doesn't connect all those domestic destinations, it's customer airlines do, and until you get a seamless connection/brand/alliance experience, you cannot maximise out that potential. However that sounds like BA Connect and that didn't work too well. However it will be tried again I am sure and good luck to who ever cracks it
Flybe is trying this again, and has done so for about 18 months.
It has the seamless domestic operation (I assume its seamless as flybe have said 20% of its MAN passengers are connecting and I have not heard of any horror stories).
It also connects onto Etihad and Air France flights and no doubt some others too.
Yes, its not LHR or BA level of hubbing, but Rome wasn't built in a day.