I think we already see a move away from the "Pilot" being in charge of the aircraft.
The Captain is becoming more of a manager, in some cases during non normal operations, we the (Captains) are being encouraged to leave the flying to the F/O and focus on managing the situation (which I can not fault).
In the military we see more and more unmanned vehicles, I wouldn't be surprised if, within 10 years there is a low cost carrier springing up without humans on the flight deck. The flight will be flown by a "Pilot" sitting on a desk on the ground. The argument will be: oh we can send astronauts to and around the moon on automatic, we can certainly assure the same level of safety to passengers on board our aircraft without pilots on board, after all, they will say, the Pilot is the weakest link in the chain. Of course there will be lots of statistics to back up the argument and low low ticket prices to attract those who are willing to take the chance and they will!
Eventually, we will see one human supervising 3-4 flights each carrying 500 - 600 fun seekers to popular plastic vacation spots.
Then, the select few real Pilots will be flying exclusive corporate aircraft or flying for fun.