An interesting thread. Personally I think we will one day see pilot-less commercial flights, but it's a long long way off. Look at the airliners being made/designed now (A350,787, Neo, Max). They will be in operation for the next 20+ years and they haven't even considered not having 2 pilots.
The next logical step would be to introduce UAVs for non-passenger roles (crop-spraying, aerial surveying etc). Then I think we might move to 1 pilot cockpit designs, where the plane all but flies itself and the pilot is purely a back-up. Then eventually we could have pilot-less airliners, but it's a long way off.