Our 380 miles rescue also had 2 refuels, they did 200+380x2+200, so almost 1200 miles, 12 hours or so, and to the West of the Azores you are literally in the middle of the Atlantic, these are very uncomfortable flights. The 380 leg was made from (and to) an airport that has no VOR or ILS, just a NDB, and the closest viable alternate is 200 miles away.
The weather is very bad in the winter (45+ kts, BKN002, etc), but I'm sure not as bad as in the North Sea!
Best wishes from sunny Portugal