the largest aircraft in the US Airways portfolio, and it's little to do with the patronage of Astra-Zeneca
Actually Astra Zeneca has a lot to do with the A330-300.
Astra used to used Continental to Newark, which is why we saw the DC-10 and then B777-200.
It was no co-incidence that once the contract switched to US Airways, the route quickly dropped to a B767-400 and then down to a B757-200.
Whilst I do not see the route being dropped, I do see it being downgraded. Its already gone to a slightly smaller A330-200, and even the B767 has made an appearance this month for the first time in years!
The only thing that could keep an airbus on the route is freight, but, even that seems to be in an ever downward spiral at MAN.