I think we are getting a little off message but
A 350 would only carry a few thousand litres of oxygen in an EMS role. If you have a leak of more than a couple of litres a minute you will very soon put your patient at risk due to inadequate oxygen. If the leak is in the pipeline you will also immediately be unable to provide high flow oxygen again putting the patient at risk. If is happens in a hospital it is a major reportable event. in the UK at least we use hospital standard pipelines in aircraft. Leaving a flow meter turned on with 4 litres a minute running is hardly an issue
A LOX is a totally different system from cylinders. The oxygen is low pressure and liquified. Spillage of high volumes of gaseous oxygen cannot occur because the portable systems vaporisation systems are only capable of 10 to 20 litres a minute. That is why we can't run high consumption equipment such as heart lung machines off LOX. Of course, in a high G impact the actual container can rupture leading to leakage of liquid oxygen. But otherwise it is so safe that we have clearance to carry 50000 litres on commercial flights
There appears no evidence to implicate oxygen in this accident, but having spent many years getting LOX approved by the CAA I am keen to ensure the excellent safety record is not besmirched