This is stating the obvious but it's worth asking oneself if ME is really needed.
When I was starting my PPL in 2000, everybody said to me "when will you be moving up to twins". It was the "in" thing back then. You got a PPL, then ME, and then you got bored and dropped out of flying
By the time I got going on reasonable trips, I lost any interest in ME as a potential purchase. I have just 1.5hrs in my logbook, done in a very posh C421C. Mr Thielert p*ssed on the "affordable ME" bonfire well and truly, and down with it went the avtur option which would be so great in southern Europe.
Today, avgas costs make a piston twin quite pricey to operate - unless it has two Rotaxes in which case you need a spare one anyway
The jury is still out (or yet again out) on the DA42TDi and it will be a few years before anybody can trust it for long trips. Singles do offer quite a lot, especially if you can stretch to a PT6 engined plane like the Jetprop
Not wishing to start another SE v. ME debate