On the face of it yes, I mean BA used to fly B747s on the MAN-HKG route into the late 80s (I think?). 135,000 pa = ~370 per day currently split between BA / EK / EY / QR / BD & STAR. That's one B744 for the entire market split over multiple carriers.
The 135,000 figure is the pax routing through LHR. Let's tag on the all the pax routing through other airports. I'm sure you'd be looking at going on for 200,000 pax. Now that takes to over 500 a day. May be not worth a 744 daily but a nice 77W/772 with the advantage of taking up cargo. But even if they did do that to pay lip service to the regions, they'd find a way to make it not work as per normal BA practices.