Hello,
First thing,
Before dispatching your aircraft, you must ensure 1#out ok throughout the flight ! Otherwise, no go or an alternative must be found.
This is the regulation.
Concerning your question, where have you found a min alt of 22000ft ? Not over Europe I guess... Nevertheless,
Second, you must indeed respect the minimum grid altitude or MEA etc... (this taking into account low qnh or low temperature affects on your altimetry.)
Do not forget, you will have to descend if you are high but it will take a certain distance/time before you reach your recovery altitude. (drift down).
The remaining engine is at MCT ! you won't descend like a brick at your best glide speed ok ?
By that time, hopefully you have decided on a good track considering terrain and you will be above your min altitudes.
Good drift !
Flyer146