The biggest thing that will kill you is just plain old fatigue. The money or toys or so-called "job security" (don't
up now sonny!), none of it matters when you're Just. Plain. Tired. All the time. You will quite literally be selling yourself physically, every bit as much as the two-bit whores at Rattlesnakes. Even the happy-clappy multi-year apologists have to admit it has changed radically over the last 2 years. The recovery time between flights just isn't there.
Even on the 380...does anyone really think they will enjoy their rosters the way they are forever? Not when the greedy little pricks who run the show have seen how they were able to use the Global Economic Crisis as an excuse to screw their employees as hard as they could for massive profits. If anyone thinks they're trying to bring the 777/330/340 rosters to the point the 380 rosters are, and not the other way around, they are seriously deluded.
The other factor being, you will not know what it's like living in a place where the overall system is run by one that promotes hate, that tries to divide all humanity into two classes, "brothers" and unbelievers. If that sort of thing appeals to you and you really think that the accumulation of a little bit of wealth is the end-all, be-all perhaps you will enjoy it.