I think the first jets with more than two engines which was two crew were the 757/767,
AFAIK there has never been either a 757 or 767 with more than two engines....
I believe the first two crew civil airliner with more than two engines would have been the MD11, closely followed by the 747-400.
Mt first ever trip was on a 1-11, operated by Maersk Air UK in BA Landor livery from BHX to BFS in 1995. Unfortunately, only being 10 years old at the time I didn't realise the significance of this beautiful machine. Would have asked for a flight deck visit if I had! I reckon we should sod the Euro noise regulations and bring back the old metal
