I feel a lot of these scenarios aren't really as much LOFT as they are details. With regards to Centaurus post, the discussion of LOFT-or-not vs use of avaliable sim time, that's an interesting an on-going discussion, but not exactly what the thread starter was asking, perhaps.
A few possible scenarios:
Planned flight from A to B with close to minimum fuel and generally poor weather, requiring takeoff alternate etc. Let flight progress normally and introduce a system failure close to destination, along with busy traffic. Everything sorted out, landing in conditions close to minimums, but nothing out of the ordinary.
Planned flight from A to B, engine fire on climbout, go to takeoff alternate which then becomes below minimums, and have the crew go somewhere else.
The point of the LOFT excercise as far as I'm aware, is to get out of the simulator V1-cut mentality, where you pretty much know what will happen. It is to practice crm, normal and abnormal procedures in a realistic setting. Ask yourself how many accident reports you've read that included an engine failure around V1 and how many included loss of situational awareness due to something that could easily be percieved as a minor event?
And again; the answer may very well be that LOFT scenarios are a waste of time compared to drilling maneuvers. I don't know, but that's a whole other discussion.