none of the major American airlines are currently interested.
Considering that only two even fly the B747 in ever decreasing numbers, that's not saying much. The B747 lost money for years and years, no one KNOWS what will happen with the A380 program, but it has had issues and come to market late, at a time of international economic crisis. Much like the B747 and the oil crisis, remember the B747 nearly died in the late 1970s and buying 25 of them killed Pan Am as they never filled them and were overtaken by the series 200s.
Only time will tell, I look forward to seeing what BA do with them.