You know, that's too big a question!
It's like asking "what is life like?"
Everyone seems to concentrate on the short to medium haul regional night freight when asking and answering this question. That is by no means the accurate measure of the freight world
.
The freight side of aviation is world-wide, 24/7, and I have been lucky enough to spend almost all my adult life in the long haul wide-body world.
And, in that respect, it is no different from the pax world, except there are no flight attendants and no whining slf
There are nearly as many tailor-made, straight off the production line freighters as there are converted ex-pax birds.
Whether air-dropping relief supplies from an L-382 in Africa, or taking a nice shiny 744F to Singapore, it's all good
.