I don't, and I wouldn't, but I have friends who do.
It's designed as a one-security-solution-does-everything type of application, and is thus ideal for those who want the minimum possible to do with their computers security. And it's pretty good at doing that. Unfortunately, very occasionally it will detect something harmless, and maybe important, as malware, and quarantine it, often without warning the user. Result can be a borked OS. (This happened to a friend.Took a while to sort out.)
I have heard it is a bit of a resource hog, too.
If you don't know much about malware and don't mind something else taking almost total responsibility for that, it's ideal.
If you want to be more involved with what goes on under the bonnet, you can pick apps that will allow you to do that, and still be at least as well protected.