Quote: "You're making some fairly broad brush assumptions...namely that there's a safety issue associated with the -200. There isn't."
The stats seem to show that there seems to be a higher risk of 747C cargo operations than other forms of jet transport. Here are some hull losses that I can remember. (I could probably find more if I do a search).
El Al at Amsterdam.
Korean at Stanstead.
Air Atlanta at Sharjah.
MK at Kano.
MK at Halifax.
CAL at Liege.
Atlas at Dusseldorf.
Kalitta at Brussels.
Kalitta at Bogota.