Certainly there are some airspace challenges around Orlando, and at a major controlled field you burn up some hobbs time getting off the ground.
On RT, just remember that enroute, no one cares where you left from, only where you are going. Keep the transmits short, only the required info, if you go into the long explanations you hear from guys transiting in UK, you are going to really piss off some controllers. Once the controller shortens your call sign from Cessna 172AT to Cessna 2AT, that is it, just use the short version.
If you don't know or don't want to explain exactly where you are going, say out of Sanford, just tell them VFR northbound and initial altitude when you call clearance or ground. And the uncontrolled fields, Unicom, they don't want to tell you much due to liability, so don't expect much info from whoever is there, you are free to pick your own entry and runway, but obviously use common sense and don't conflict. AWOS is about all you need and all you are going to get at uncontrolled fields. Just leave out anything that they don't need on your radio calls.
Oh, and lots of people use Sir when addressing controllers, certainly not a requirement and much different conotation that in the UK. We don't envision some AH with a castle.