I have never seen it done since is was outlawed for our outfit in 1992. We have had one or two smokers (PinC) that have used nicotine patches on long flights until they get to the airport smoking area.
Smoking on board the aircraft (part 135,125 and 121) in any area is illegal in our airspace, so you would be subject to the law of the land and then sacked, and possible loss of licence for not a "fit and proper person to hold an aviation document"
So the risk for a quick dorrie could be very harsh here, so why do it?