I have several hundred hours in twins, Seneca, Duchess, Navajo, DA42 etc and now thanks to a very nice man a couple in a 421C. With the exception of the high end twins like the Navajo and the 421C the lighter twins do not offer much over and above a single other than the mindset of 2 engines.
I moved over to a Malibu, single engine but cruises at 220KTAS and upto 25,000ft pressurised with weather radar etc. All for less than the cost of operating any twin including the DA42 and much more capable.
Flying twins is great fun and requires great currency and discipline and is not something I intend on giving up but there is something rather attractive about true all weather capability and lower costs from a high end single. Yes I would cross the alps and large chunks of water. Have you seen the glide distance from 25,000ft?
The next move looks like it is going to be SET for the extra performance and ceiling.