Well....in every airlines i have flown with, it was very clear...if ANY pilot was to become incapacitated during T.O , means no answer at 80 kts from PF (or PNF do not make the call out ), do another LOUD call . If still no answer ,expect the other pilot being incapacitated. The take-off must be aborted before V1.This was trained in sim.
Now imagine you have bad weather + a major failure at, or after V1....single pilot
....what do you think it would have been safest course of action ?