Cannot see any reason why a direct service to Hong Kong, Beijing or for that matter West coast USA would not be launched within the next two or three years. Both have large economies and established or growing tourist sectors.
Neither is easily accesibile at this moment in time nearest hub for China with a flight from Manchester is Singapore, West coast USA take your pick from either mid -west or eastern sea board hubs.
With new generation 200 -250 seat airliners coming into service in the next few years these services should be profitable to operate from Manchester and it,s catchment area. The question is which operators and when.