Airbus stated intention is to design the pilot out of the Flight Deck.
The Dog and the pilot scenario is gaining more relevance.
And Boeing have also wanted this, since at least the early 1980s that I am aware of, so it will happen eventually.
There will always NEED to be some staff in the cabin though, apart from any evacuation, also to feed the pax etc, so then these people WILL BE the ONLY Onboard Managers.