Doug,
In lo-co we do a full days work followed by a night off followed by another days work etc... so we're tired after an honest day's work. In long haul we'd do a 7 hour night flight into a different time zone, have 12 hours 'rest' followed by another 7 hour flight back home (also at night). Result - no sleep for three days! And after a day at home the company would happily launch us into a 14 hour night flight to europe (don't mention the 9 day around-the-world zombie specials or the red-eye JFK-europe!). So for me, it's the comfortable high stress multi-sector lo-co all in the same time zone, anytime!!!
easy
You can't compare the two until you've done both