Latest aircraft have an ECAM warning if park brake is set in flight. Can't remember if it is being retrofitted with new software updates. I seem to remember from my distant 737 days that it had locked wheel protection, would that have helped if the park brake was set or did it just stop you bursting a tyre if your size 12s were on the brake pedals?
The operator even called in a psychologist to help them with this aspect.
If it's the one I am thinking of then I am sure he was a great help