Define large jet? Why large jet?
Yes, I have quite a few hours on piston twins and yes, now a captain on a jet. Albeit not a large one but I'd hazard a guess I do more challenging flying.
Twin flying was bush charter and scenic along with specialist mission work.
Any experience in a commercial operation is good. If you're being paid to fly and to make command decisions, the experience is invaluable.
If the difference means you have 500 hours versus 250 hours, then go for it.