Door seal- leak can be contained. Automatic warning and emergency systems would have stopped an excessive loss of pressure. The pilots would have checked the pressurisation condition. Did she ask them if there was anything unusual afterwards?
The cabin crew can become convinced there is something wrong, and it can become very difficult to persuade them all is normal. I have seen this many times. They convince each other the pilots 'have done something' to the pressurisation, and they can hardly breath. Just a few weeks ago, I was faced with a delegation that came to the flight deck and said they had been talking in the rear galley 'and they were all suffering the same symptoms- they had all never been on a flight where they were so seriously passing wind as they were today, and what was wrong?'. It was hard to keep a serious, straight face. One thought 'well maybe it would be better not to have the curry crew meal!', but this was one of those times not to be flippant or tell a joke. The pressurisation was absolutely normal with both packs delivering full volume air. But women talk, and they become convinced, and they are all quite certain 'there was something wrong that day'.
I think maybe your wife had a bad day (women do.....frequently). They get far more headaches than us men. Maybe the noise was unpleasant and gave her one. We had a faulty door seal on a positioning flight. The level of noise is intense and startling. I would say there really was nothing wrong.....but you can't convince them of that.