not a problem if you are in the right place,friend of mine out of oxford,no flying job for 2 years,spotted advert in HKG for SIA 747 freighter first officer position.applied and is now on the 400f,HKG resident card certainly helped,but hours proved not to be an issue.pass the type rating and you can fly the aircraft,just not that many opportunities for a rookie to jump straight onto a heavy jet.