My worst memory of this was when flying from Gatwick in 1987. A couple, youngish, fore-runners of chavs, were both so p*ssed that they had to walk along the wall edge to the gate just to stay even slightly vertical. She was slightly less far gone than him, knew that the flight was imminent and had to keep pulling him from the waste bins that he was heaving into.
I still wonder if they were allowed to board - I do hope not.
I was once so short of sleep (but totally sober) on a take-off from Brize that I was asleep before take-off. Luckily I woke up in time to put on my parachute