I don't know why 2 or 3 A/P's make a diff.? Both are CAT III auto land's are they not?
The 7 cabin crew that you need on the 75 will make a differance on cost aswell as the general upkeep of a/c and burning more fuel due larger empty wt and bigger engines etc.
Extra seats are a given but you have to sell those seats due you not?
I am not sure what the performance of the 757 is for short RWY'S but I would say and this is a guess here. That the 73-800 has comparable performance if not better.
On leace prices etc Well it depends who you are and what you got them for. Transavia most probably got a totally differant deal to Ryanair on the 800's.
Charters have made the 75 work for them for many years though. So they do work!