Might be time to bring up the EMS safety record in the USA again...last two fatal accidents have been in SPIFR machines at night in bad weather...one enroute to a home base at an airport...now this one enroute to an airport from a hospital.
The other worrisome issue might be the fact they were both Agusta machines and no radio calls were made by the pilots reporting a problem of any kind to ATC.
Condolences to the family of all the four crewmembers lost in the two crashes....and hopefully, causes of the crashes can be determined in a timely manner and determine if any simularities exist that might work towards preventing a third event.