A medical costs about €200, an ATPL renewal about €350 and the sim, I don't know how much for Ryanair but Aer Lingus used to rent out their 737-200 sim for €300 per hour, so figure on substantially more than that for an NG sim (+ ryanairs cut), multiply by 8 for one 2 day session then by 2 for the cost per year. Then add the hotac, sustenance and flight costs.... So a substantial amount I would guess.