Can only speak for the -200F. Lots of the guys live all over Europe and seem to have no trouble commuting to LHR, FRA, CDG, etc. A mix of ID travel and LCC's seem to be used. I don't think it is painful but sometimes the crews end up finishing a pattern away from their home port which is frustrating. Do not expect any favours from rostering with regard to commuters!!
Good Luck
LCC