Well, at least some military pilots will be replaced:
"...Congress last year set a goal of making a third of deep-first-strike aircraft in the U.S. fleet unmanned by 2010."
from:
http://www.latimes.com/business/la-011902drone.story
A couple of the major cargo operators are known to be funding serious studies of pilotless planes. "Scope" is a very novel concept in the freight dog business.
At some point in the near future, airline contracts will have an automation section. Perhaps pilots will be grandfathered like Profession Flight Engineers in the old ALPA contracts.
I figure pilots have at least as much job security versus automation as elevator operators.