Depends what you want and you take on the career/life balance.
I work low cost. The hours are way too long to give you any sort of a life. Great when you're starting out-lots of flying , quick command. Not when you're not.
Smaller airlines give you a better life generally than the major ones as you have much more control over what and when you do you thing. And after you've turned down the neighbour's 3rd invitaion to lunch cos you're working, that matters believe you me.