As a personal rule, if I'm not familiar with the fix, I'll ask ATC to give me an "initial heading" to the fix, ask them to spell it for positive I.D. and then "punch it in the box". If it all agrees my partner and I will pull up the Lat. and Long. and I.D. it on the enroute chart, verify the next fix with ATC and make sure the "lads in the chairs" haven't given us a point in space that is a clearance limit. Seems to keep me out of trouble.